CJC-1295 (without DAC)

What is CJC-1295 Without DAC?

CJC-1295 Without DAC (also known as Modified GRF 1-29 or Mod-GRF 1-29) is a modified GHRH analogue that retains the four amino acid substitutions that extend its half-life from 7 minutes (native GHRH) to approximately 30 minutes — without the Drug Affinity Complex (DAC) that would further extend it to days.

This 30-minute activity window makes CJC-1295 Without DAC ideal for producing defined, pulsatile GH release that closely mimics the body's natural GH secretory pattern. It is the preferred GHRH analogue for research protocols that value physiological GH pulsatility over chronic GH elevation.

Mechanism of Action

CJC-1295 Without DAC binds GHRH receptors on anterior pituitary somatotrophs and stimulates GH synthesis and secretion. The four amino acid modifications (Ala at position 2, Gln at position 8, Ala at position 15, Leu at position 27) protect the peptide from rapid enzymatic degradation while preserving full GHRH receptor affinity.

The result is a compound that stimulates a clean, defined GH pulse approximately 30 minutes in duration — creating a pharmacokinetic profile suitable for mimicking the physiological GH pulses that occur 4-8 times per day in healthy young adults.

Why Pulsatile GH Release Matters

GH receptors undergo downregulation in response to chronic, continuous stimulation. Research consistently shows that pulsatile GH patterns produce superior anabolic and lipolytic effects compared to continuous GH exposure at equivalent total doses. This is why pulsatile GH release (which Mod-GRF 1-29 facilitates) may produce better long-term results for body composition and anti-aging research than the chronic elevation produced by CJC-1295 With DAC.

The Gold Standard Combination: CJC-1295 Without DAC + Ipamorelin

By combining CJC-1295 Without DAC (GHRH receptor agonist) with Ipamorelin (GHSR agonist), researchers can activate both independent GH secretory pathways simultaneously. The resulting GH pulse is 8-10 times greater than either compound alone — a synergistic rather than additive effect that has made this combination the most widely studied GH peptide stack in research.

*For research use only. Not for human consumption.*