5-AMINO-1MQ
Promotes fat loss by increasing fat breakdown.
Research Benefits
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Pantheon Peptides
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What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of NNMT (Nicotinamide N-methyltransferase) — an enzyme that plays a central role in cellular metabolism, adipogenesis, and energy expenditure regulation. By blocking NNMT, 5-Amino-1MQ increases NAD+ and SAM (S-adenosylmethionine) availability while simultaneously inhibiting the epigenetic pathways that promote fat cell expansion.
Mechanism of Action
NNMT Inhibition
NNMT catalyzes the transfer of a methyl group from SAM to nicotinamide, producing 1-methylnicotinamide and consuming SAM in the process. High NNMT activity is associated with increased adipogenesis, reduced energy expenditure, and metabolic dysfunction. By inhibiting NNMT, 5-Amino-1MQ preserves SAM and enhances NAD+ availability.
NAD+ Enhancement
Increased NAD+ availability activates sirtuins (SIRT1, SIRT3) — protein deacetylases that improve mitochondrial function, insulin sensitivity, and energy expenditure. This positions 5-Amino-1MQ as an indirect NAD+ booster with metabolic effects analogous to NMN or NR supplementation.
Adipogenesis Inhibition
NNMT promotes adipogenesis through epigenetic mechanisms. Its inhibition by 5-Amino-1MQ reduces the epigenetic marks that drive fat cell differentiation and lipid accumulation, effectively slowing the creation of new fat cells.
Key Research Findings
Animal studies have demonstrated significant fat loss and improved metabolic markers with 5-Amino-1MQ administration. Importantly, the fat loss occurs without caloric restriction — suggesting direct effects on energy expenditure and adipose metabolism. The compound also shows promise for insulin sensitivity improvement and may have applications in metabolic syndrome research.
*For research use only. Not for human consumption.*
Research Use Only: This product is for laboratory research purposes only. Not intended for human consumption. Not approved by the FDA for any therapeutic use. Consult a qualified physician before any use.
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